4th Century CE
- The Dominion is founded by a group of Changelings who settle on a rogue planet in the Gamma Quadrant.
- A group of Vulcans, who do not agree with the teachings of Surak leave their homeworld Vulcan.
9th Century CE
- Kahless the Unforgettable unites the Klingon people after his defeat of the tyrant Molor and the Fek'Ihri. Kahless establishes a strict warrior code that is passed down through Klingon culture to the present day.
14th Century CE
- The Nacene, a group of nonhumanoid extragalactic explorers, visit the Ocampa homeworld in the Delta Quadrant. They unwittingly cause the eradication of all nucleogenic particles from the planet's atmosphere. Two Nacene choose to remain and protect the Ocampa from the damage they caused.
| Distant Past | Timeline | 19th Century |